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Adnane Achour


Adnane Achour

Karolinska Institutet, Sweden

Biography

Adnane Achour has experience in both Structural Biology and Immunology. The research group uses X-ray crystallography and small angle X-ray scattering (SAXS) to study receptor-ligand interactions between T or NK cell receptors and Major Histocompatibility Complex (MHC) molecules, as well as bacterial adhesins and virulence-associated molecules. All the studies are complemented by a wide array of immunological assays as well as an extensive amount of biochemical techniques, including surface plasmon resonance and circular dichroism. By understanding the structural details of proteins, we can probe their function and potentially design artificial ligands that could modulate their function and activity.

Abstract

Abstract : Rigidification of MHC-I/peptide complexes is an essential step for enhanced T cell recognition of cancer-associated neo-epitopes associated with impaired processing