Yan Jing Fan
Chonbuk National University Medical School, Republic of South Korea
Title: Fructus Amomi alleviates inflammation in a OVA-induced allergic rhinitis mouse model
Biography
Biography: Yan Jing Fan
Abstract
Fructus Amomi Cardamomi (FA) is the mature fruit of Amomum villosum Lour of the family Zingiberaceae. It has been used in Chinese medicine for the treatment of a variety of gastrointestinal disorders. However, the anti-allergic rhinitis effects of FA are less known. We investigated the immunomodulatory effect of FA on allergic inflammation in an allergic rhinitis (AR) mouse model. Administrated by nasal installation of FA (10, 20, 40 mg/kg) ameliorated the nasal symptom and alleviated the swelling of nasal epithelium. FA reduced the goblet cell number and eosinophil number in nasal epithelium. FA also inhibited the lung hyperplasia in lung tissue. Meanwhile, FA treatment groups evidently decreased the expression of Th2 cytokines (IL-4, IL-5), increased the secretion of Th1 cytokines (IL-12, IFN-γ) in lung homogenate. FA also reduces the OVA-specific IgE and OVA-specific IgG1 level in serum. In this study, our data suggests that FA has a significant anti-allergic inflammation effect and it may prove to be an efficacious therapeutic regent on allergic rhinitis.