Thi Tho Bui
Chonbuk National University Medical School, Republic of Korea
Title: Bupleurum chinense extract against nasal inflammation by inhibiting eosinophil and mast cell activation in OVA-induced allergic rhinitis mouse model
Biography
Biography: Thi Tho Bui
Abstract
Bupleurum Chinense has been used as traditional herbal medicine for more than a thousand years. It has been found to have anti-inflammatory, anti-oxidant, hepato-protective, antipyretic, analgesic, anti-fibrotic and immunomodulatory effect. However, the effect of B. Chinense on allergic rhinitis remains unclear. We clarified whether or not Bupleurum Chinense extracts (BCE) could ameliorate inflammatory response in OVA-induced AR mice model. The oral administrations of BCE inhibited the accumulation of eosinophils in NALF (nasal lavage fluid) and nasal epithelium and their active production such as CCL24. BCE may also prevented allergic response via suppressing mast cells accumulation in nasal epithelium and serum histamine release simultaneously with inhibiting the serum anti-OVA IgE, IgG1 and elevating the anti-OVA IgG2a at BCE dose-dependent treatment. Accordingly, nasal epithelial swelling and goblet cells hyperplasia were clearly attenuated. In addition, BCE regulated the balance of Th1, Th2 and Treg-related cytokines that could prevent inflammatory cells activation such as eosinophils ans mast cells; briefly; down-regulated the expression of IL-4, IL-5, IL-13 in NALF and nasal tissue and up-regulated the secretion of IL-10, IL-12 and IFN-γ. These results suggest that BCE may have therapeutic potential for treating allergic rhinitis by preventing the accumulation and activation of the inflammatory cells such as eosinophils and mast cells.