Kimihiko Okazaki
Okazaki Medical Clinic, Japan
Title: Basis of the novel concept that antibodies mutually exchange on the receptors
Biography
Biography: Kimihiko Okazaki
Abstract
Although it is well established that an equilibrium state exists among antibody molecules in the vicinity of their receptors on the surface of immune cells, namely, cytolytic T lymphocytes and mast cells, it has long been taken for granted that molecular substitutions of antibodies on their receptors never occur. Obviously, these two concepts disagree with each other because existence of equilibrium state itself indicates that every molecule of antibody keeps changing its status being attached to or detached from its receptor. In addition, a certain molecule of antibody does not necessarily attach to one certain receptor. In other words, every receptor of antibody keeps changing antibodies. The alternative concept, namely, molecular substitutions of antibodies on their receptors do occur all the time, is extremely useful. Reason is that the concept can be applied to complete cure of immune diseases; allergies and autoimmune diseases, and there is another reason that the pathogen specific antibodies can be replaced by harmless non-specific antibodies if the latter are accumulated in patients’ bodies. The necessary and sufficient condition for the accumulation is to repeat injecting the patient with non-specific antigens.